Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

MA Hossain; CM Smith; PJ Ryan; E Büchler; RAD Bathgate; AL Gundlach; JD Wade

Journal article

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

MA Hossain, CM Smith, PJ Ryan, E Büchler, RAD Bathgate, AL Gundlach, JD Wade

Amino Acids | SPRINGER WIEN | Published : 2013

DOI: 10.1007/s00726-013-1478-0

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Abstract

The insulin-like peptide, relaxin-3 was first identified just a decade ago via a genomic database search and is now recognized to be a key neuropeptide with several roles including the regulation of arousal, stress responses and neuroendocrine homeostasis. It also has significant potential as a drug to treat stress and obesity. Its actions are mediated via its cognate G protein-coupled receptor, RXFP3, which is found in abundant numbers in the brain. However, much remains to be determined with respect to the mechanism of neurological action of this peptide. Consequently, the chemical synthesis of the rat and mouse (which share identical primary structures) two-chain, three disulfide peptide ..

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University of Melbourne Researchers

Akhter Hossain Author

Ross Bathgate Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was funded by NHMRC (Australia) project Grants 508995, and 1023078 to JDW, MAH and RADB and 1005988 to ALG and RADB. We are grateful to Tania Ferraro and Sharon Layfield for assistance with biochemical assays and to Feng Lin for amino acid analysis. MAH was the recipient of a Florey Foundation Fellowship and RADB, ALG and JDW are NHMRC (Australia) Research Fellows. Research at the Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program.